Distinguish a mixture, where substances combine but keep their properties and can be separated, from a chemical reaction that forms a new substance.
When you stir together trail mix, raisins, nuts, and pretzels, you still have raisins, nuts, and pretzels. That is a mixture: the parts keep their own properties and can usually be sorted back out. Salt water is also a mixture; you could evaporate the water and get the salt back.
Sometimes, though, mixing two substances makes something brand new that behaves completely differently and cannot be un-mixed back into the originals. Baking soda and vinegar combine and fizz into carbon dioxide gas and other new substances; you cannot separate that fizzing gas back into plain baking soda and vinegar. That kind of change forms a new substance and is evidence of a chemical reaction.
Mastery looks like: They can sort a set of examples into mixture or new substance formed, using the separate-back-out test and reaction clues.
Common stumbles: Assuming any mixing counts as a chemical reaction; missing that a color or temperature change is meaningful evidence.